Matrixyl 3000 Peptide

Matrixyl 3000 is a trademarked peptide composition developed by Sederma Inc. in France. It is the first anti-aging ingredient based on the matrikine peptide technology. Matrixyl 3000 is composed of the matrikines palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7.

These two peptides work synergistically to restore and maintain the skin’s youthful appearance by signaling to cells to produce more collagen. Numerous studies have proven the anti-aging and anti-wrinkle efficacy of Matrixyl 3000.

For example, a clinical study involving female participants demonstrated that after just 2 months of treatment with Matrixyl 3000, the area occupied by deep wrinkles was reduced by 45%, and the skin’s tonicity increased by nearly 20%. In a separate 2 month clinical study conducted on a panel of men, the anti-wrinkle efficacy of Matrixyl 3000 was confirmed. As the wrinkle volume decreases (-17.1%), the spread angle increases (+5.4%), which leads to a reduction of the surface occupied by deep wrinkles of nearly 30%.

Another peptide complex by Sederma Inc. is Matrixyl synthe’6. It is composed of palmitoyl tripeptide-38, a peptide derived from the tripeptide KMK naturally found in collagen VI and laminin. In-vitro studies have found Matrixyl synthe’6 to have a matrikine-like effect that stimulates the synthesis of collagen I, II, IV, fibronectin, hyaluronic acid, and laminin 5.